Downstream effects of reduction in nucleotide excision repair in response to cisplatin treatment in melanoma

Title: Downstream effects of reduction in nucleotide excision repair in response to cisplatin treatment in melanoma
Creator: Bowden, N. A.; Ashton, K. A.; Avery-Kiejda, K. A.; Zhang, X. D.; Hersey, P.; Scott, R. J.
Relation: 2011 International Melanoma Congress. Pigment Cell & Melanoma Research (Tampa, FL 9-13 November, 2011) p. 1028-1029
Publisher Link: http://dx.doi.org/10.1111/j.1755-148X.2011.00909.x
Publisher: Wiley-Blackwell Publishing
Resource Type: conference paper
Date: 2011
Description: We have confirmed that the GGR regulators, BRCA1 and PCNA, are induced in normal cellular response to cisplatin induced DNA damage, but there is complete absence of induction of these regulators in melanoma cell lines. In addition, we identified highly significant overlap of transcript expression in melanoma cell lines after cisplatin treatment with transcripts highly correlated with the DNA doublestrand break repair genes BRCA1, BRCA2, ATM and CHEK2. Finally, we confirmed complete lack of induction of XPB in melanoma cell lines and a significant overlap of transcript expression with XPB deficient cells after UVR.
Subject: GGR regulators; cellular response; cisplatin; DNA damage
Identifier: http://hdl.handle.net/1959.13/1036319
Identifier: uon:13256
Identifier: ISSN:1755-148X
Language: eng

		Thumbnail	File	Description	Size	Format